血清硬化蛋白或可预测绝经后女性的骨密度

大山

       导语：骨密度是骨质疏松症诊断和预测的主要指标，现已发现多种基因与骨密度相关。硬化蛋白与骨细胞、成骨细胞的LRP5/6受体结合，拮抗Wnt/b-catenin信号通路，在调解骨骼对机械负荷中发挥重要作用。为此，上海交通大学章振林教授等就血清骨硬化蛋白水平及其基因的单核苷酸多肽性位点（SNPs），与骨密度、骨代谢指标之间的关系进行了研究。
       标签：血清硬化蛋白  绝经后女性  骨密度

       骨密度是骨质疏松症诊断和预测的主要指标，现已发现多种基因与骨密度相关。硬化蛋白与骨细胞、成骨细胞的LRP5/6受体结合，拮抗Wnt/b-catenin信号通路，在调解骨骼对机械负荷中发挥重要作用。为此，上海交通大学章振林教授等就血清骨硬化蛋白水平及其基因的单核苷酸多肽性位点（SNPs），与骨密度、骨代谢指标之间的关系进行了研究。
　　该横断面研究共纳入703例中国绝经后女性，检测SOST基因的10个SNPs位点，同时测量血清硬化蛋白、血清全段甲状旁腺激素、25（OH）D、1型前胶N端前肽（P1NP）和1型胶原交联羧基端肽β-CrossLaps（β-CTX）的水平，并使用双能X线吸收测定法对腰椎和股骨近端的BMD进行评估。
　　研究结果显示，血清硬化蛋白水平与腰椎、股骨颈、全髋部的BMD，以及25（OH）D呈正相关，与β-CTX呈负相关。校正年龄、BMI和血清25（OH）D后，血清硬化蛋白与BMD、β-CTX仍存在相关性。
　　但是，血清硬化蛋白与年龄、血清P1NP不存在相关性。同时，SOST基因SNP单倍型与BMD、血清硬化蛋白或骨代谢指标之间也不存在明显相关性，说明SOST基因多肽性并非中国绝经后女性血清硬化蛋白或BMD变化的主要原因。
　　研究结果提示，血清硬化蛋白水平或可间接预测绝经后女性BMD的变化，可帮助评估其骨质疏松性骨折的风险。
原文阅读：
       Associations of Serum Sclerostin and Polymorphisms in the SOST Gene with Bone Mineral Density and Markers of Bone Metabolism in Postmenopausal Chinese Women.
　　Abstract
　　Objective: The aims of this study were to （1） evaluate the association of serum sclerostin with bone mineral density （BMD） and markers of bone metabolism in postmenopausal Chinese women and （2） observe the relationships of single nucleotide polymorphisms （SNPs） within the sclerostin （SOST） gene with serum sclerostin, BMD, and markers of bone metabolism. Design: A cross-sectional study was conducted with 703 postmenopausal Chinese women. Ten tagging SNPs （rs1234612, rs1513670, rs1634330, rs1708635, rs2023794, rs7220711, rs74252774, rs851057, rs851058, and rs865429） of the SOST gene were genotyped. Serum sclerostin and markers of bone metabolismwere measured, including serum intact parathyroid hormone, 25-hydroxyvitamin D [25（OH）D], procollagen type 1 N-terminal propeptide （P1NP）， and β-CrossLaps of type I collagen containing cross-linked C-telopeptide （β-CTX）。 The BMD of the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry. Results: Serum sclerostin was positively correlated with BMD at lumbar spine, femoral neck, total hip and with serum 25（OH）D （all P<0.01）， but negatively correlated with β-CTX （P<0.01）。 The significant relationships between serum sclerostin and BMD and with serum β-CTX persisted even after adjustments for age, BMI and serum 25（OH）D （all P<0.01）。 However, there was no correlation between serum sclerostin and age or serum P1NP. We failed to identify a significant association between the SNP, haplotypes of SOST and BMD, serum sclerostin, or markers of bone metabolism. Conclusion: Our results suggested that serum sclerostin was positively correlated with the BMD at lumbar spine, femoral neck, total hip and with serum 25（OH）D but was negatively correlated with serum β-CTX. Genetic polymorphisms of SOST may not be a major contributor to variations in the serum sclerostin or BMD in postmenopausal Chinese women.